Breast ultrasound in 22,131 asymptomatic women with negative mammography

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• 作者：Veronica Girardi ; Mara Tonegutti ; Stefano Ciatto ; Franco Bonetti
• 关键词：Breast neoplasm ; Screening ; Mammography ; Ultrasonography
• 刊名：The Breast
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：22
• 期：5
• 页码：806-809
• 全文大小：180 K

文摘

Purpose

To evaluate increment cancer detection rate generated by ultrasound (US).

Materials and methods

US only detected cancers were assessed for 22,131 self-referring asymptomatic women with negative mammography and subgroups by age, previous cancer, breast density. Invasive assessment and surgical biopsy rate were evaluated.

Results

The overall US detection was 1.85 per thousand (41/22,131). In the subgroups it was: 1.95 per thousand (22/11,274) in women <50 years vs 1.75 per thousand (19/10,857) in women ¡Ý50 years (p?=?0.42), 5.49 per thousand (12/2183) in women with previous cancer vs 1.45 per thousand (29/19,948) in women without cancer history (p?=?0.0004), 2.21 per thousand (22/9960) in dense breasts (p?=?0.17) vs 1.56 per thousand (19/12,171) in fatty breasts. The US generated invasive assessment was 1.9 % (422/22,131). The benign to malignant open surgical biopsy ratio was 0.17 (7/41).

Conclusion

Adding US to negative mammography allowed for substantial incremental cancer detection rate (1.85 per thousand), particularly at age <50years, in women with previous breast cancer and in dense breasts.