PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain
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- 作者：Jennine M. Dawicki-McKenna1 ; 5 ; Marie-France Langelier3 ; 4 ; 5 ; Jamie E. DeNizio1 ; 2 ; Amanda A. Riccio3 ; 4 ; Connie D. Cao1 ; Kelly R. Karch1 ; 2 ; Michael McCauley3 ; Jamin D. Steffen3 ; Ben E. Black1 ; 2 ; blackbe@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author ; John M. Pascal3 ; 4 ; john.pascal@umontreal.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：3 December 2015
- 年：2015
- 卷：60
- 期：5
- 页码：755-768
- 全文大小：4526 K
文摘
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HXMS reveals dramatic changes in PARP-1 dynamics upon binding to DNA damage
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The HD subdomain locally unfolds when PARP-1 is bound to DNA damage
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The HD is an autoinhibitory domain that blocks productive binding to NAD+
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X-ray structures of constitutively active PARPs are determined bound to inhibitors