Next generation sequencing of microRNAs from isogenic neuroblastoma cell lines isolated before and after treatment
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- 作者：Sarah Andrea Rotha ; Erik Knutsenb ; Tonje Fiskaab ; Peter Utnesc ; Swapnil Bhavsara ; Ø ; yvind H. Haldc ; Cecilie Lø ; kkea ; Pieter Mestdaghd ; Steinar D. Johansenb ; e ; Trond Flæ ; gstada ; c ; Christer Einvika ; c ; christer.einvik@uit.no" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuroblastoma ; microRNA ; miRNA ; 14q32 miRNA cluster ; Drug resistance ; Next generation sequencing ; SOLiD
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：372
- 期：1
- 页码：128-136
- 全文大小：997 K
文摘
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RNAseq of neuroblastoma cell lines isolated pre- and post treatment.
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Identified 42 differentially expressed miRNAs.
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8 miRNAs were upregulated and 34 were downregulated.
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65% of the downregulated miRNAs are encoded by the 14q32 miRNA clusters.
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Reduced expression of 14q32 miRNAs in tumors is associated with poor prognosis factors.
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IPA reveals functions and pathways associated with cancer progression and drug resistance.