- 作者：Franz Porzsolt ; Anja Wirth ; Regine Mayer-Steinacker ; Michael Schulte ; Giovanni Negri ; Peter Suhr ; Karl-Heinz Link ; Wilhelm Gaus ; Erwin M. Rottinger
- 关键词：Breast cancer ; prognostic factors ; sites of relapse ; response rates ; survival ; adjuvant chemotherapy
- 刊名：Cancer Treatment Reviews
- 出版年：1996
- 出版时间：January 1996
- 年：1996
- 卷：22
- 期：Supplement 1
- 页码：41-49
- 全文大小：551 K
The clinical problems of 171 cancer patients were discussed in the Interdisciplinary Oncologic Conference (IOC) of the Cancer Centre University of Ulm (CCUU) and recommendations concerning further diagnostic treatments and/or therapy were provided. These recommendations had been documented and analysed retrospectively.
The goals were classified as either cure or palliation or further investigation. If the goal was palliation, it was investigated whether or not the goal was specified as either alleviation of existing problems or prevention of impending problems. The achievement of the specified goals was assessed.
Palliation was the goal of treatment in 119 (71 % ) of the 168 evaluable recommendations. In 83 of the 119 cases (70 % ), immediate treatment was recommended. The goal was specified in 57 (69 % ) of the 83 recommendations and could be realized in 24 of 57 specified cases (42 % ). Patients in this group survived longer (p <0.01) than patients in whom the goals could not be achieved. Impending problems could be prevented more often (p=0.001) in 14 out of 18 cases, while existing problems could be alleviated in only 10 out of 34 cases.
It is concluded that specification of the goals of palliation is necessary because it is impossible to decide if a goal of treatment could be achieved or not unless the goal of treatment has been defined (as existing/impending problem). The prevention of impending problems could be investigated in prospectively controlled clinical trials.