Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity
详细信息 查看全文
- 作者：Sheng Yaoa ; b ; 1 ; Kenneth Kin-Wah Tob ; c ; 1 ; Liang Maa ; b ; Chun Yinb ; d ; Chunping Tanga ; b ; Stella Chaib ; d ; Chang-Qiang Kea ; b ; Ge Linb ; d ; linge@cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author ; Yang Yea ; b ; e ; yye@mail.shcnc.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Marsdenia tenacissima ; Asclepiadaceae ; C21 steroids ; Open-chain sugars ; Absolute configuration ; X-ray crystallography diffraction ; Chemoresistance reversal activity ; Structure elucidation
- 刊名：Phytochemistry
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：126
- 期：Complete
- 页码：47-58
- 全文大小：1493 K
文摘
- •
A polyoxypregnane aglycone and four polyoxypregnane steroids were isolated from Marsdenia tenacissima.
- •
The polyoxypregnane steroids are naturally occurring polyoxypregnane glycosides bearing an open-chain sugar moiety.
- •
Two of these compounds exhibited a wide spectrum of chemoresistance reversal activity.
- •
Potential mechanisms were studied.