Proteasome activation enhances stemness and lifespan of human mesenchymal stem cells

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• 作者：Marianna Kapetanou^a ; ^b ; Niki Chondrogianni^a ; ^{nikichon@eie.gr} ; Spyros Petrakis^c ; George Koliakos^c ; ^d ; Efstathios S. Gonos^a ; ^{sgonos@eie.gr}
• 关键词：MSC ; Mesenchymal Stem Cell ; hMSC ; human Mesenchymal Stem Cell ; WJ ; Wharton's Jelly ; ASC ; Adipose Stem Cell ; CPDs ; Cumulative Population Doublings ; CT-L ; Chymotrypsin-Like ; T-L ; Trypsin Like ; PGPH ; Peptidylglutamyl-peptide hydrolyzing ; ROS ; Reactive Oxygen Species ; RNAi ; RNA interference ; siRNA ; short interfering RNA ; ChIP ; Chromatin Immune Precipitation ; Oe ; overexpression
• 刊名：Free Radical Biology and Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：103
• 期：Complete
• 页码：226-235
• 全文大小：1578 K
• 卷排序：103

文摘

Proteasome dysfunction is linked with the senescence-related decline of MSC function. Proteasome activation through β5 overexpression promotes MSCs stemness. The expression of proteasome subunits is affected by pluripotency factors. Oct4 possibly regulates the expression of β2 and β5 proteasome subunits by binding to their promoter region.