Transcription of Mammalian cis-Regulatory Elements Is Restrained by Actively Enforced Early Termination
详细信息 查看全文
- 作者：Liv M.I. Austenaa1 ; 4 ; liv.austenaa@ieo.eu" class="auth_mail" title="E-mail the corresponding author ; Iros Barozzi1 ; 4 ; 5 ; Marta Simonatto1 ; 4 ; Silvia Masella1 ; Giulia Della Chiara1 ; Serena Ghisletti1 ; Alessia Curina1 ; Elzo de Wit2 ; 6 ; Britta A.M. Bouwman2 ; Stefano de Pretis3 ; Viviana Piccolo1 ; Alberto Termanini1 ; Elena Prosperini1 ; Mattia Pelizzola3 ; Wouter de Laat2 ; Gioacchino Natoli1 ; gioacchino.natoli@ieo.eu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：5 November 2015
- 年：2015
- 卷：60
- 期：3
- 页码：460-474
- 全文大小：5695 K
文摘
- •
Enhancers and promoters produce Pol II-dependent short ncRNAs
- •
WDR82 targets to Pol II both the SET1 H3K4 methyltransferase and the PP1 phosphatase
- •
Depletion of WDR82, SET1, or PP1 impaired Pol II transcription termination
- •
Enhancers and promoters generated long and abundant ncRNAs upon WDR82 depletion