Anticancer copper pyridine benzimidazole complexes: ROS generation, biomolecule interactions, and cytotoxicity

详细信息    查看全文

• 作者：Kathleen E. Prosser ; Stephanie W. Chang ; Felix Saraci ; Phuc H. Le ; Charles J. Walsby ; ^{cwalsby@sfu.ca}
• 关键词：Copper ; Anticancer ; Reactive oxygen species ; Albumin ; DNA
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：89-99
• 全文大小：1095 K
• 卷排序：167

文摘

Synergy between copper centres and ligands generates cytotoxicity. Coordinate and non-coordinate interactions with albumin. Complexes cause DNA cleavage in the presence of ascorbate via hydroxyl radicals. Complexes generate elevated levels of reactive oxygen species in A549 cells.