TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection
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- 作者：Ulrike Schleicher1 ; 2 ; 10 ; Katrin Paduch1 ; 10 ; Andrea Debus1 ; 10 ; Stephanie Obermeyer1 ; Till Kö ; nig3 ; 12 ; Jessica C. Kling4 ; 13 ; Eliana Ribechini5 ; Diana Dudziak2 ; 6 ; Dimitrios Mougiakakos2 ; 7 ; Peter J. Murray8 ; Renato Ostuni9 ; 14 ; Heinrich Kö ; rner4 ; 11 ; Christian Bogdan1 ; 2 ; 11 ; christian.bogdan@uk-erlangen.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：3 May 2016
- 年：2016
- 卷：15
- 期：5
- 页码：1062-1075
- 全文大小：5611 K
文摘
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TNF inhibits IL-4-induced Arg1 expression in macrophages and dendritic cells
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Arg1 is upregulated in macrophages or dendritic cells of L. major-infected TNF−/− mice
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Arg1 hyperexpression in TNF−/− mice impairs in situ production of leishmanicidal NO
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Arg1 deletion restores parasite and disease control in otherwise non-healing mice