Merkel cells are long-lived cells whose production is stimulated by skin injury

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• 作者：Margaret C. Wright^a ; ^{mcw47@pitt.edu} ; Gregory J. Logan^b ; Alexa M. Bolock^c ; Adam C. Kubicki^c ; Julie A. Hemphill^c ; Timothy A. Sanders^d ; Stephen M. Maricich^c ; ¹ ; ^{stephen.maricich@bmrn.edu}
• 关键词：DTA ; diphtheria toxin subunit A ; E ; embryonic age ; EdU ; 5-ethynyl-2&prime ; -deoxyuridine ; GFP ; green fluorescent protein ; K8 ; Keratin 8 ; MCC ; Merkel cell carcinoma ; P ; postnatal age in days ; SA1 ; slowly adapting type 1 afferent ; YFP ; yellow fluorescent protein
• 刊名：Developmental Biology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：422
• 期：1
• 页码：4-13
• 全文大小：1524 K
• 卷排序：422

文摘

Embryonic Merkel cells persist long into adulthood. Average Merkel cell number does not change with the hair cycle. Few Merkel cells are generated in adulthood. Skin shaving induces Merkel cell production. Merkel cells likely arise from proliferation of Gli1+ progenitors.