Heterocyclic acetamide and benzamide derivatives as potent and selective β₃-adrenergic receptor agonists with improved rodent pharmacokinetic profiles

详细信息    查看全文

• 作者：Stephen D. Goble ; Liping Wang ; K. Lulu Howell ; Alka Bansal ; Richard Berger ; Linda Brockunier ; Jerry DiSalvo ; Scott Feighner ; Bart Harper ; Jiafang He ; Am ; a Hurley ; Donna Hreniuk ; Emma Parmee ; Michael R
• 关键词：β ; ₃ Adrenergic receptor agonist ; Overactive bladder
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2010
• 出版时间：15 March 2010
• 年：2010
• 卷：20
• 期：6
• 页码：1895-1899
• 全文大小：426 K

文摘

A series of amide derived β₃-adrenergic receptor (AR) agonists is described. The discovery and optimization of several series of compounds derived from 1, is used to lay the SAR foundation for second generation β₃-AR agonists for the treatment of overactive bladder.