Bilirubin inhibits the up-regulation of inducible nitric oxide synthase by scavenging reactive oxygen species generated by the toll-like receptor 4-dependent activation of NADPH oxidase
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- 作者：Gila Idelman ; Darcey L.H. Smith ; Stephen D. Zucker ; zuckersd@ucmail.uc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aryl hydrocarbon receptor (AhR) ; Bilirubin ; Hypoxia-inducible factor (HIF) ; NADPH oxidase ; Nitric oxide synthase ; Toll-like receptor 4 (TLR4) ; Superoxide
- 刊名：Redox Biology
- 出版年：2015
- 出版时间：August 2015
- 年：2015
- 卷：5
- 期：Complete
- 页码：398-408
- 全文大小：797 K
文摘
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Bilirubin blocks TLR4 signaling by scavenging NADPH oxidase-derived reactive oxygen species.
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Bilirubin specifically inhibits the TRIF-dependent TLR4 signaling pathway.
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LPS activation of inducible nitric oxide synthase is mediated by HIF-1α.
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Macrophages exhibit reciprocal regulation of HIF-1α and aryl hydrocarbon receptor pathways.
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Potential mechanisms underlying the anti-inflammatory effects of bilirubin are delineated.