Surgical Salvage of Thermal Ablation Failures for Renal Cell Carcinoma

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• 作者：Juan A. Jimé ; nez^a ; ^&lowast ; ; Zhiling Zhang^a ; ^&lowast ; ; Juping Zhao^a ; ^&lowast ; ; Robert Abouassaly^b ; ^&lowast ; ; Amr Fergany^a ; ^&lowast ; ; Michael Gong^a ; ^&lowast ; ; Jihad Kaouk^a ; ^&dagger ; ; Venkatesh Krishnamurthi^a ; ^&lowast ; ; Robert Stein^a ; ^&lowast ; ; Andrew Stephenson^a ; ^&lowast ; ; Steven C. Campbell^a ; ^&lowast ; ; ^{campbes3@ccf.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：carcinoma ; renal cell ; cryosurgery ; ablation techniques ; neoplasm recurrence ; local ; nephrectomy
• 刊名：The Journal of Urology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：195
• 期：3
• 页码：594-600
• 全文大小：282 K

文摘

Cryoablation and radio frequency ablation are attractive modalities for small renal masses in patients with substantial comorbidities. However, salvage extirpative therapy for local recurrence after thermal ablation can be challenging due to associated perinephric fibrosis.

Materials and Methods

Patients with thermal ablation refractory tumors requiring surgical salvage from 1997 to 2013 were identified and retrospectively reviewed.

Results

A total of 27 patients were treated surgically after cryoablation (18) or radio frequency ablation (9) failed. Subjective assessment indicated moderate/severe fibrosis in 22 cases (81%). Partial nephrectomy was preferred in all patients but was not possible in 12, primarily due to unfavorable tumor size/location. In the intended partial nephrectomy group (15) open surgery was performed in all patients and completed in 14, with the procedure aborted in 1 due to extensive perinephric fibrosis. Radical nephrectomy was planned in 12 patients, of whom 8 were treated laparoscopically with 1 requiring conversion to open. Median estimated blood loss was 225 ml. Overall 17 patients experienced no complications and 4 had minor complications. However, 6 patients experienced more significant complications (Clavien III-IVb). Since January 2008 partial nephrectomy was performed more frequently (12 of 17, or 71% vs 2 of 10, or 20% for previous cases, p=0.02).

Conclusions

Surgical salvage after failed thermal ablation is feasible in most instances, and partial nephrectomy is often possible but can be challenging due to associated perinephric fibrosis. The difficulty of surgical salvage should be recognized as a potential limitation of the thermal ablation treatment strategy. Prospective studies of thermal ablation vs partial nephrectomy should be prioritized to provide higher quality data about the merits and limitations of each approach.