Characterisation of transcriptional responses to dioxins and dioxin-like contaminants in roach (Rutilus rutilus) using whole transcriptome analysis
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- 作者：Markus Brinkmanna ; 1 ; Sven Koglina ; 1 ; Bryanna Eisnerb ; Steve Wisemanb ; Markus Heckerb ; c ; Kathrin Eichbauma ; Beat Thalmanna ; Sebastian Buchingerd ; Georg Reifferscheidd ; Henner Hollerta ; e ; f ; g ; henner.hollert@bio5.rwth-aachen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aryl hydrocarbon receptor ; ClueGO ; Illumina sequencing ; Next-generation sequencing ; RNAseq ; Transcriptomics
- 刊名：Science of the Total Environment
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：541
- 期：Complete
- 页码：412-423
- 全文大小：1462 K
文摘
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DLCs induced transcriptional responses in roach (Rutilus rutilus).
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Despite equipotent doses, marked differences were observed between three DLCs.
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TCDD provoked specific effects on immunotoxicity and carbohydrate metabolism.
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Exposure to PCB 156 caused the least specific effects.
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BkF affected the most diverse suite of molecular functions and biological processes.