Fasciola hepatica demonstrates high levels of genetic diversity, a lack of population structure and high gene flow: possible implications for drug resistance

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• 作者：Nicola J. Beesley^a ; ^{nbeesley@liverpool.ac.uk} ; Diana J.L. Williams^a ; Steve Paterson^b ; Jane Hodgkinson^a
• 关键词：Fasciola hepatica ; Population genetics ; Anthelmintic resistance ; Diversity ; Self-fertilisation ; Gene flow ; Microsatellites
• 刊名：International Journal for Parasitology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：47
• 期：1
• 页码：11-20
• 全文大小：903 K
• 卷排序：47

文摘

Self-fertilisation does occur but is rare in field populations of Fasciola hepatica. Some hosts harboured genotypically identical parasites (clones). The presence of clones is consistent with clonal expansion and clumped transmission. 84% of 1579 F. hepatica had unique genotypes, indicating high genetic diversity. We found high gene flow, no population structure and low self-fertilisation rate.