Synthesis and evaluation of 3′-azido-2′,3′-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus
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- 作者：Hong-wang Zhang ; Steven J. Coats ; Lavanya Bondada ; Franck Amblard ; Mervi Detorio ; Ghazia Asif ; Emilie Fromentin ; Sarah Solomon ; Aleks ; r Obikhod ; Tony Whitaker ; Nicolas Sluis-Cremer ; John W. Mellors ; R
- 关键词：HIV-1 ; Nucleoside ; Antiviral ; Transglycosylation
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2010
- 出版时间：1 January 2010
- 年：2010
- 卷：20
- 期：1
- 页码：60-64
- 全文大小：307 K
文摘
Based on the promising drug resistance profile and potent anti-HIV activity of β-d-3′-azido-2′,3′-dideoxyguanosine, a series of purine modified nucleosides were synthesized by a chemical transglycosylation reaction and evaluated for their antiviral activity, cytotoxicity, and intracellular metabolism. Among the synthesized compounds, several show potent and selective anti-HIV activity in primary lymphocytes.