Synthesis of the putative structures of homopumiliotoxins 235C and 233F

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• 作者：Armstrong ; Paul ; Feutren ; Stephanie ; McAlonan ; Helena ; O’ ; Mahony ; Gavin ; Stevenson ; Paul J.
• 关键词：Homopumiliotoxin alkaloids ; Heck reaction
• 刊名：Tetrahedron Letters
• 出版年：2004
• 出版时间：February 16, 2004
• 年：2004
• 卷：45
• 期：8
• 页码：1627-1630
• 全文大小：275 K

文摘

A novel approach to diene based quinolizidines, using an intramolecular Heck reaction in which the vinyl bromide double bond undergoes inversion of configuration, is reported. These quinolizidines have previously been proposed as tentative structures for homopumiliotoxin alkaloids 233F and 235C. The mass spectral data of the synthetic materials were different to those of the natural products confirming that the original structures need to be revised.