Cellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology

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• 作者：Ramaswamy Krishnan¹ ; Jin-Ah Park² ; Chun Y. Seow³ ; Peter V-S. Lee⁴ ; Alastair G. Stewart⁵ ; ^{astew@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author}
• 关键词：mechanobiology ; drug screening ; stiffness ; stress ; strain ; traction
• 刊名：Trends in Pharmacological Sciences
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：37
• 期：2
• 页码：87-100
• 全文大小：2391 K

文摘

The study of mechanobiology is now widespread. The impact of cell and tissue mechanics on cellular responses is well appreciated. However, knowledge of the impact of cell and tissue mechanics on pharmacological responsiveness, and its application to drug screening and mechanistic investigations, have been very limited in scope. We emphasize the need for a heightened awareness of the important bidirectional influence of drugs and biomechanics in all living systems. We propose that the term ‘mechanopharmacology’ be applied to approaches that employ in vitro systems, biomechanically appropriate to the relevant (patho)physiology, to identify new drugs and drug targets. This article describes the models and techniques that are being developed to transform drug screening and evaluation, ranging from a 2D environment to the dynamic 3D environment of the target expressed in the disease of interest.