The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats鈥擜 comparative study
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- 作者：Franti&scaron ; ek Bá ; rtaa ; Kate艡ina Levová ; a ; Eva Freib ; Heinz H. Schmeiserc ; Volker M. Arltd ; Marie Stiborová ; a ; stiborov@natur.cuni.cz" class="auth_mail
- 关键词：AA ; aristolochic acid ; AAI ; aristolochic acid I ; AAIa ; aristolochic acid Ia ; AANAAII ; aristolochic acid II ; AAN ; aristolochic acid nephropathy ; BEN ; Balkan endemic nephropathy ; CYP ; cytochrome P450 ; dA-AAI ; 7-(deoxyadenosin-N6-yl)-aristolactam I ; dG-AAI ; 7-(deoxyguanosin-N2-yl)aristolactam I ; dA-AAII ; 7-(deoxyadenosin-N6-yl)aristolactam II ; HRN ; Hepatic P450 Reductase Null ; IARC ; International Agency for Research on Cancer ; NQO1 ; NAD(P)H ; quinone oxidoreductase ; POR ; NADPH ; P450 oxidoreductase ; RA
- 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- 出版年：1 July 2014
- 年：2014
- 卷：768
- 期：Complete
- 页码：1-7
- 全文大小：1260 K
文摘
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NAD(P)H:quinone oxidoreductase expression in liver, kidney and lung of mice and rats.
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Organ specificity of expression of this enzyme.
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Reductive activation of the nephrotoxic and carcinogenic aristolochic acid I (AAI).
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NAD(P)H:quinone oxidoreductase is induced in mice and rats treated with AAI.
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Induced hepatic and renal enzyme activity resulted in elevated AAI-DNA adduct levels.