Acquired cold urticaria: Clinical features, particular phenotypes, and disease course in a tertiary care center cohort

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• 作者：Gustavo Deza ; MD^a ; ^{gustavo.deza@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ana Brasileiro ; MD^a ; ^b ; Marta Bertolí ; n-Colilla ; MD^a ; Laia Curto-Barredo ; MD^a ; Ramon M. Pujol ; MD ; PhD^a ; Ana M. Gimé ; nez-Arnau ; MD ; PhD^a
• 关键词：acquired cold urticaria ; disease course ; phenotypes ; physical urticaria
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：75
• 期：5
• 页码：918-924.e2
• 全文大小：494 K

文摘

Data about special phenotypes, natural course, and prognostic variables of patients with acquired cold urticaria (ACU) are scarce.

Objectives

We sought to describe the clinical features and disease course of patients with ACU, with special attention paid to particular phenotypes, and to examine possible parameters that could predict the evolution of the disease.

Methods

This study was a retrospective chart review of 74 patients with ACU who visited a tertiary referral center of urticaria between 2005 and 2015.

Results

Fourteen patients (18.9%) presented with life-threatening reactions after cold exposure, and 21 (28.4%) showed negative results after cold stimulation tests (classified as atypical ACU). Nineteen patients (25.7%) achieved complete symptoms resolution at the end of the surveillance period and had no subsequent recurrences. Higher rates of atypical ACU along with a lower likelihood of achieving complete symptom resolution was observed in patients who had an onset of symptoms during childhood (P < .05). In patients with atypical ACU, shorter disease duration and lower doses of antihistamines required for achieving disease control were detected (P < .05). Age at disease onset, symptom severity, and cold urticaria threshold values were found to be related to disease evolution (P < .05).

Limitations

This study was limited by its retrospective nature.

Conclusions

The knowledge of the clinical predictors of the disease evolution along with the clinical features of ACU phenotypes would allow for the establishment of an early and proper therapeutic strategy.