Anti-Müllerian hormone, antral follicle count and follicle-stimulating hormone for predicting the number of oocytes retrieved in IVF/ICSI cycles

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• 作者：Jie-ru ZHU^a ; Jian-ping OU^a ; ^{oujianping@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Wei-jie XING^a ; Wei-hao LI^a ; Wei-jie ZHU^b ; ^{tzhuwj@jnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：anti-Mü ; llerian hormone (AMH) ; antral follicle count (AFC) ; follicle-stimulating hormone (FSH) ; ovarian response
• 刊名：Journal of Reproduction and Contraception
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：27
• 期：2
• 页码：89-93
• 全文大小：280 K

文摘

To evaluate the efficacy of anti-Müllerian hormone (AMH), antral follicle count (AFC) and follicle-stimulating hormone (FSH) for predicting the number of oocytes retrieved in in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles.

Methods

In this retrospective study, a total of 122 infertile women were divided into two groups: group A, <35 years (n=71); group B, ≥35 years (n=51). AMH and FSH were determined on 2-5 d of the early menstrual cycle. AFC was tested on the second day of the menstrual cycle before the start of stimulation.

Results

Group B had higher FSH levels compared with group A (8.2±3.5 IU/L vs 6.8±2.4 IU/L, P<0.05). However, levels of AMH and AFC in group B were lower than those of group A (AMH: 4.2±3.5 μg/L vs 2.7±2.7 μg/L; AFC: 9.0±3.9 vs 5.4±3.3, P<0.05). The number of oocyte retrieved in the two groups was not significantly different (11.5±6.8 vs 9.6±6.9, P>0.05). The level of AMH was more strongly correlated with the number of oocytes retrieved than that of AFC or FSH level. The strengths of the correlation degrees were AMH level, AFC, and FSH level in turn (r=0.600, 0.511, −0.369).

Conclusion

AMH would be a useful predictor for ovarian response.