Oleic acid induces specific alterations in the morphology, gene expression and steroid hormone production of cultured bovine granulosa cells
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- 作者：Vengala Rao Yenuganti ; Torsten Viergutz ; Jens Vanselow ; vanselow@fbn-dummerstorf.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：BHBH ; beta-hydroxy butyric acid ; CD36 ; cluster of differentiation 36 ; CL ; corpus luteum ; CREB-CBP ; cAMP regulatory element-binding protein complex ; CCND2 ; cyclin-D2 ; CYP11A1 ; cytochrome P450 ; family 11 ; subfamily A ; polypeptide 1 ; CYP19A1 ; cytochrome P450 ; family 19 ; subfamily A ; polypeptide 1 ; FSH ; follicle-stimulating hormone ; FSHR ; follicle-stimulating hormone receptor ; HSD3B1 ; hydroxy-delta-5-steroid dehydrogenase ; 3 beta- and steroid delta-isomerase 1 ; IGF1 ; insulin-like growth factor 1 ; LH
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：232
- 期：Complete
- 页码：134-144
- 全文大小：2454 K
文摘
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Oleic acid extensively changed the morphology of cultured bovine granulosa cells.
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Oleic acid induced the expression of CD36 and SLC27A, and lipid droplet formation.
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Oleic acid down regulated the expression of CYP19A1, STAR, CYP11A1 and HSD3B1.
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Oleic acid reduced estradiol and progesterone levels along with FSHR and LHCGR.
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Effects of oleic acid might be due to the reduced responsiveness to FSH stimulation.