Intracortical Inhibition Assessed with Paired-Pulse Transcranial Magnetic Stimulation is Modulated during Shortening and Lengthening Contractions in Young and Old Adults
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- 作者：George M. Opie ; John G. Semmler ; john.semmler@adelaide.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMT ; active motor threshold ; SP ; silent period ; FDI ; first dorsal interosseous muscle ; fMRI ; functional magnetic resonance imaging ; GABA ; gamma aminobutyric acid ; LICI ; long-interval intracortical inhibition ; M1 ; primary motor cortex ; MCP ; metacarpophalangeal joint ; MEP ; motor evoked potential ; MSO ; maximum stimulator output ; MVC ; maximum voluntary contraction ; RMT ; resting motor threshold ; SICI ; short-interval intracortical inhibition ; TMS ; transcranial magnetic stimulation
- 刊名：Brain Stimulation
- 出版年：2016
- 出版时间：March-April 2016
- 年：2016
- 卷：9
- 期：2
- 页码：258-267
- 全文大小：630 K
文摘
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We used paired-pulse TMS to examine age-related differences in intracortical inhibition (ICI) during shortening and lengthening contractions.
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Short-interval ICI was reduced during both movements in all subjects, with greater reductions observed during lengthening contractions in older adults.
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Long-interval ICI was increased during both movement tasks in young but not old subjects.
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These findings suggest that shortening and lengthening contractions modulate GABAergic inhibition, and that this is altered by healthy ageing.