TMS combined with EEG in genetic generalized epilepsy: A phase II diagnostic accuracy study

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• 作者：Vasilios K. Kimiskidis^a ; ^{kimiskid@auth.gr} ; Alkiviadis Tsimpiris^b ; ^{alkisser@auth.gr} ; Philippe Ryvlin^c ; ^d ; ^{ryvlin@cermep.fr} ; Reetta Kalviainen^e ; ^f ; ^{reetta.kalviainen@kuh.fi} ; Michalis Koutroumanidis^g ; ^h ; ^{Michael.Koutroumanidis@gstt.nhs.uk} ; Antonio Valentinⁱ ; ^j ; ^k ; ^{Antonio.valentin@kcl.ac.uk} ; Nikolaos Laskaris^l ; ^m ; ^{laskaris@aiia.csd.auth.gr} ; Dimitris Kugiumtzis^b ; ^{dkugiu@auth.gr}
• 关键词：TMS&ndash ; EEG ; TMS combined with EEG ; GGE ; genetic generalized epilepsies ; AEDs ; antiepileptic drugs ; HV ; hyperventilation ; EDs ; epileptiform discharges ; TMS ; Transcranial Magnetic Stimulation ; TEPs ; TMS-evoked potentials ; SI ; stimulus intensity ; MSO ; maximum stimulator output ; LEThr ; lower epileptogenic threshold ; UEThr ; upper epileptogenic threshold ; ISI ; inter-stimulus interval ; MDS ; multi-dimensional scaling
• 刊名：Clinical Neurophysiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：128
• 期：2
• 页码：367-381
• 全文大小：4128 K
• 卷排序：128

文摘

A paired-pulse TMS–EEG protocol with multi-level data analysis is presented. The accuracy of TMS–EEG for differentiating genetic generalized epilepsy (GGE) patients from controls is high. TMS–EEG differentiates responders from non-responders to antiepileptic drugs in GGE.