The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation
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- 作者：Makiko Iwafuchi-Doi1 ; Greg Donahue1 ; Akshay Kakumanu3 ; Jason A. Watts1 ; Shaun Mahony3 ; B. Franklin Pugh3 ; Dolim Lee2 ; Klaus H. Kaestner2 ; Kenneth S. Zaret1 ; zaret@upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：7 April 2016
- 年：2016
- 卷：62
- 期：1
- 页码：79-91
- 全文大小：3235 K
文摘
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Liver-specific enhancers retain accessible nucleosomes more than ubiquitous enhancers
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FoxA binding displaces linker histone and keeps nucleosomes accessible
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FoxA2 is enriched near the dyad axis of accessible nucleosomes with other liver TFs
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FoxA-bound nucleosomes at enhancers stimulate liver gene activation