Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

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• 作者：Rahajeng N. Tunjungputri^a ; ^b ; ^{Rahajeng.Tunjungputri@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author} ; Marien I. de Jonge^c ; Astrid de Greeff^d ; Saskia van Selm^c ; Herma Buys^d ; Jose F. Harders-Westerveen^d ; Norbert Stockhofe-Zurwieden^d ; Rolf T. Urbanus^e ; Phillip G. de Groot^a ; ^e ; Hilde E. Smith^d ; Andre J. van der Ven^a ; Quirijn de Mast^a
• 关键词：Platelets ; Pneumonia ; Streptococcus pneumoniae ; Myocardial infarction ; Platelet activation ; Infection
• 刊名：Thrombosis Research
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：144
• 期：Complete
• 页码：123-126
• 全文大小：498 K

文摘

Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.