Characterization of immune responses following homologous reinfection of pigs with European subtype 1 and 3 porcine reproductive and respiratory syndrome virus strains that differ in virulence
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- 作者：Eefke Weesendorpa ; eefke.weesendorp@wur.nl" class="auth_mail" title="E-mail the corresponding author ; Norbert Stockhofe-Zurwiedena ; Hans J. Nauwynckb ; Ditta J. Popma-De Graafa ; Johanna M.J. Rebela
- 关键词：Genetic subtypes ; Homologous reinfection ; Protection ; Immune response ; Porcine reproductive and respiratory syndrome virus
- 刊名：Veterinary Microbiology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：182
- 期：Complete
- 页码：64-74
- 全文大小：578 K
文摘
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We studied the effect of homologous challenge of EU subtype 1 and 3 PRRSV.
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Subtype 3 induced stronger inflammatory responses than 1 after primo infection.
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There were no differences between subtype 1 and 3 in protection after challenge.
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Adaptive responses were comparable between subtype 1 and 3 infection.
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Differences in in-vitro heterologous responses require further research.