Altered neuroantigen-specific cytokine secretion in a Th2 environment reduces experimental autoimmune encephalomyelitis
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- 作者：Stefanie J. Kirwin ; Kenichi C. Dowdell ; Claudia Hindinger ; Ni Feng ; Cornelia C. Bergmann ; David R. Hinton and Stephen A. Stohlman
- 关键词：Autoimmunity ; Th1/Th2 cells ; EAE/MS
- 刊名：Journal of Neuroimmunology
- 出版年：2006
- 出版时间：September 2006
- 年：2006
- 卷：178
- 期：1-2
- 页码：30-39
- 全文大小：535 K
文摘
Activation of Th2 cells suppresses clinical experimental autoimmune encephalitis (EAE), demyelination and expression of genes associated with Th1-mediated inflammation. Despite both reduced central nervous system inflammation and IFN-γ induced MHC class II expression by microglia, the composition of CNS infiltrates in Th2-protected mice were similar to mice with EAE. Analysis of the CNS infiltrating cells by flow cytometry suggests that protection did not correlate with abrogation of CD4+ T cell recruitment, preferential recruitment of donor Th2 cells or an increased frequency of CD25+ CD4+ T cells. By contrast, protection correlated with an increased frequency of neuroantigen-specific Th2 cells infiltrating the CNS. These data suggest that a peripheral Th2 cytokine environment influences both potential antigen presenting cells as well as recruitment and/or retention of neuroAg-specific Th2 CD4+ T cells.