Patients with Ehlers Danlos syndrome and CRPS: A possible association?

详细信息    查看全文

• 作者：Joan M. Stoler and Anne Louise Oaklander
• 关键词：Connective tissue ; Pain ; Inherited disorder of collagen ; Genetics ; Reflex sympathetic dystrophy
• 刊名：Pain
• 出版年：2006
• 出版时间：July 2006
• 年：2006
• 卷：123
• 期：1-2
• 页码：204-209
• 全文大小：143 K

文摘

Rare patients are left with chronic pain, vasodysregulation, and other symptoms that define complex regional pain syndrome (CRPS), after limb traumas. The predisposing factors are unknown. Genetic factors undoubtedly contribute, but have not yet been identified. We report four CRPS patients also diagnosed with the classical or hypermobility forms of Ehlers Danlos syndrome (EDS), inherited disorders of connective tissue. These patients had been diagnosed using standard diagnostic criteria for CRPS and for EDS. All had sustained joint injury; in three this had been surgically treated. The association of these two diagnoses leads us to hypothesize that EDS might contribute to the development of CRPS in one or more of the following ways: via stretch injury to nerves traversing hypermobile joints, increased fragility of nerve connective tissue, or nerve trauma from more frequent surgery. We review the clinical presentation of the different Ehlers Danlos syndromes and provide clinical criteria that can be used to screen CRPS patients for EDS for clinical or research purposes.