Band 3, the human red cell chloride/bicarbonate anion exchanger (AE1, SLC4A1), in a structural context
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- 作者：Reinhart A.F. Reithmeiera ; r.reithmeier@utoronto.ca" class="auth_mail" title="E-mail the corresponding author ; Joseph R. Caseyb ; Antreas C. Kallic ; Mark S.P. Sansomc ; Yilmaz Algueld ; So Iwatad
- 关键词：Anion exchanger ; Band 3 ; Bicarbonate transport ; Chloride/bicarbonate exchange ; Distal renal tubular acidosis (dRTA) ; Glycoprotein ; Hereditary spherocytosis (HS) ; Hereditary stomatocytosis (HSt) ; Membrane proteins ; Molecular dynamics ; N-glycosylation ; Protein folding ; Protein quality control ; Solute carrier 4 (SLC4) ; Southeast Asian ovalocytosis (SAO) ; Trafficking ; Transporters
- 刊名：Biochimica et Biophysica Acta (BBA)-Biomembranes
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1858
- 期：7
- 页码：1507-1532
- 全文大小：1724 K
文摘
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The Band 3 chloride/bicarbonate anion exchanger 1 (AE1, SLC4A1) is one of the best-studied human membrane transport proteins.
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A recent 3.5 Å crystal structure of the Band 3 membrane domain provides new insights into its mechanism of action.
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This review places over 40 year of research on Band 3 into a structural context and explains why mutations lead to disease.
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Molecular dynamics simulations produced the first molecular model of Band 3 in a lipid bilayer.