A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis
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- 作者：Jasreen Kular1 ; 5 ; Kaitlin G. Scheer1 ; 5 ; Natasha T. Pyne1 ; Amr H. Allam2 ; Anthony N. Pollard1 ; Astrid Magenau2 ; Rebecca L. Wright1 ; Natasha Kolesnikoff1 ; Paul A. Moretti1 ; Lena Wullkopf2 ; Frank C. Stomski1 ; Allison J. Cowin3 ; Joanna M. Woodcock1 ; Michele A. Grimbaldeston1 ; 4 ; Stuart M. Pitson1 ; 4 ; Paul Timpson2 ; Hayley S. Ramshaw1 ; 4 ; Angel F. Lopez1 ; 4 ; Michael S. Samuel1 ; 4 ; michael.samuel@unisa.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：14-3-3ζ ; ROCK ; mechano-reciprocity ; mechano-transduction ; MYPT ; wound healing ; re-epithelialization ; RhoA ; RhoC
- 刊名：Developmental Cell
- 出版年：2015
- 出版时间：21 December 2015
- 年：2015
- 卷：35
- 期：6
- 页码：759-774
- 全文大小：6879 K
文摘
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14-3-3ζ deficiency or inhibition enhances signaling flux through ROCK
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Increased signaling via ROCK boosts mechano-reciprocity, accelerating wound healing
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14-3-3ζ binds Mypt1, promoting its function and enhancing pMlc dephosphorylation
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14-3-3ζ deficiency increases tumor size