Impact of storage conditions on the urinary metabolomics fingerprint

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• 作者：Jé ; rô ; me Laparre^a ; ¹ ; Zied Kaabia^a ; ¹ ; Mark Mooney^b ; Tom Buckley^c ; Mark Sherry^d ; Bruno Le Bizec^a ; Gaud Dervilly-Pinel^a ; ^{gaud.dervilly@oniris-nantes.fr}
• 关键词：Urine ; Storage ; Stability ; Metabolite profiling ; Metabolites data base
• 刊名：Analytica Chimica Acta
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：951
• 期：Complete
• 页码：99-107
• 全文大小：1065 K
• 卷排序：951

文摘

HILIC and RPLC chromatographies were used for an exhaustive metabolomic approach. A chemical database was created (n > 200) to identify affected urine metabolites. Urine metabolic profile is altered starting from 5 days following storage at +4C°. A number of urine metabolites profiles start being altered after a month at −20C°. −80 °C was considered as the most convenient urine long-term storage condition.