m>Om>-Mannosylation initiates at the translocon complex in the endoplasmic reticulum (ER).
m>Om>-Man glycans can mark and exclude unfavorable folding intermediates (UPOM).
m>Om>-Mannosylation is an integral part of the interlinked ER protein homeostasis network.
New insights from high throughput MS-based glycoproteomics are discussed.
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