文摘
KM/rd and B6/rd mice display autosomal recessive hereditary retinal degeneration. The mutation point of KM/rd and B6/rd is the nonsense mutation that converts the codon 347 (TAC) to a stop codon (TAA). KM/rd and B6/rd are proved to be rd1, indicating that they can be used as an mouse mode1 of retinitis pigmentosa (RP). KM/rd and B6/rd are the first RP mouse model in China from an outbreed strain, which is more similar to human reproduction.