Clinically isolated enterovirus A71 subgenogroup C4 strain with lethal pathogenicity in 14-day-old mice and the application as an EV-A71 mouse infection model

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• 作者：Yi Xu^a ; ¹ ; Shuzhi Ma^b ; ^c ; ¹ ; Limeng Zhu^c ; Zhiqiu Huang^b ; Liyun Chen^b ; Yuhua Xu^b ; ^c ; Haibin Yin^b ; Tao Peng^b ; ^c ; ^{peng_tao@gibh.ac.cn} ; Yi Wang^b ; ^d ; ^{wang_yi79@hotmail.com}
• 关键词：Enterovirus A71 (EV-A71) ; Mouse infection model ; Primary isolate ; Vaccine
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：67-75
• 全文大小：2696 K
• 卷排序：137

文摘

GZ-CII, an EV-A71 subgenogroup C4 strain, was highly virulent in mice. Intraperitoneal infection of GZ-CII in 14-day-old mice resulted in progressive neural pathological diseases and even death. VP2-K149I mutation enhanced the virulence of EV-A71 subgenogroup C4 strains in mice.