Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue
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- 作者：Zahra Erami1 ; 5 ; David Herrmann2 ; 5 ; Sean C. Warren2 ; Max Nobis1 ; Ewan J. McGhee1 ; Morghan C. Lucas2 ; Wilfred Leung2 ; Nadine Reischmann2 ; Agata Mrowinska1 ; Juliane P. Schwarz1 ; Shereen Kadir1 ; James R.W. Conway2 ; Claire Vennin2 ; Saadia A. Karim1 ; Andrew D. Campbell1 ; David Gallego-Ortega2 ; Astrid Magenau2 ; Kendelle J. Murphy2 ; Rachel A. Ridgway1 ; Andrew M. Law2 ; Stacey N. Walters2 ; Shane T. Grey2 ; David R. Croucher2 ; Lei Zhang2 ; Herbert Herzog2 ; Edna C. Hardeman3 ; Peter W. Gunning4 ; Christopher J. Ormandy2 ; T.R. Jeffry Evans1 ; Douglas Strathdee1 ; Owen J. Sansom1 ; Jennifer P. Morton1 ; Kurt I. Anderson1 ; 6 ; k.anderson@beatson.gla.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Paul Timpson2 ; 6 ; p.timpson@garvan.org.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：intravital imaging ; FRAP ; E-cadherin ; Src-kinase ; pancreatic cancer ; invasion and metastasis ; cell adhesion and migration ; Kras ; p53
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：14
- 期：1
- 页码：152-167
- 全文大小：13770 K
文摘
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The E-cadherin-GFP mouse allows in situ quantification of E-cadherin mobility
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We monitored E-cadherin mobility during tissue homeostasis and disease development
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Invasive pancreatic cancer driven by mutant Kras/p53 increases E-cadherin mobility
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Dasatinib treatment reverts E-cadherin mobility and reinforces tumor cell junctions