Structure-based design of broadly protective group a streptococcal M protein-based vaccines

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• 作者：James B. Dale^a ; ^b ; ^c ; ^{jbdale@uthsc.edu} ; Pierre R. Smeesters^d ; ^e ; ^f ; ^g ; Harry S. Courtney^a ; Thomas A. Penfound^a ; Claudia M. Hohn^a ; Jeremy C. Smith^h ; ⁱ ; Jerome Y. Baudry^h ; ⁱ
• 关键词：Group A streptococcal vaccine ; M protein ; Structure-based design ; Broadly neutralizing antibodies
• 刊名：Vaccine
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：35
• 期：1
• 页码：19-26
• 全文大小：838 K
• 卷排序：35

文摘

emm clusters were used as the basis for structure-based design of vaccines. 3-D structures and physicochemical properties identified five M peptides representing 17 emm types. Pentavalent synthetic peptide vaccine antibodies reacted with all 17 M peptides in the cluster. Vaccine antibodies promoted bactericidal activity against 15/17 streptococcal emm types. Structure-based design may result in broadly protective group A streptococcal vaccines.