SLV310, a novel, potential antipsychotic, combining potent dopamine D₂ receptor antagonism with serotonin reuptake inhibition

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• 作者：van Hes ; Rolf ; Smid ; Pieter ; Stroomer ; Cees N. J. ; Tipker ; Koos ; Tulp ; Martin Th. M. ; van der Heyden ; Jan A. M. ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2003
• 出版时间：February 10, 2003
• 年：2003
• 卷：13
• 期：3
• 页码：405-408
• 全文大小：144 K

文摘

In this paper, SLV310 is presented as a novel, potential antipsychotic displaying the interesting combination of potent dopamine D₂ receptor antagonism and serotonin reuptake receptor inhibition in one molecule. As such, SLV 310 could be useful in treating a broad range of symptoms in schizophrenia. This paper describes the structure–activity relationship in a series of compounds leading to SLV310 (6b, 2-{4-[4-(5-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-butyl}-phthalimide) together with pharmacological data showing the unique profile of this compound.