A novel salt of antidiabetic drug metformin resulting from a proton transfer reaction: Synthesis, characterization, crystal structure and solution studies

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• 作者：Fatemeh Ghasemi^a ; Khaled Ghasemi^a ; ^{ghasemi.khaled@gmail.com} ; Ali Reza Rezvani^a ; Ardeshir Shokrollahi^b ; Masoud Refahi^b ; Santiago Garcí ; a-Granda^c ; ^{sgg@uniovi.es} ; ^{s.garciagranda@cinn.es} ; Rafael Mendoza-Meroñ ; o^c
• 关键词：Metformin ; 4-Hydroxy-2 ; 6-pyridinedicarboxylic acid ; Proton transfer ; X-ray structure ; Solution study
• 刊名：Journal of Molecular Structure
• 出版年：2017
• 出版时间：5 March 2017
• 年：2017
• 卷：1131
• 期：Complete
• 页码：30-35
• 全文大小：831 K
• 卷排序：1131

文摘

A novel salt of antidiabetic drug metformin resulting from a proton transfer reaction. Characterization by IR, NMR, UV–Vis spectroscopy and single crystal X-ray crystallography. Stabilization of the crystal structure as a result of the intermolecular hydrogen bonding. Investigation of equilibrium constants in solution by the potentiometric pH titration method. Agreement between the solution potentiometric studies and the results obtained from the solid state studies.