Synthesis, biological activities and structure−activity relationships for new avermectin analogues
详细信息 查看全文
- 作者：Jian Zhanga ; 1 ; Xiang Nana ; 1 ; Hai-Tao Yuc ; Pi-Le Chenga ; Yan Zhanga ; Ying-Qian Liua ; yqliu@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Shao-Yong Zhangb ; Guan-Fang Huc ; Huanxiang Liua ; ; An-Liang Chenb
- 关键词：Avermectin ; Structural modifications ; Insecticidal activities ; QSAR analysis
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：422-432
- 全文大小：1077 K
文摘
- •
Three new series of avermectin derivatives were synthesized and bioassayed.
- •
All the compounds showed potent lethal activities against three insect species.
- •
Some of compounds exhibited higher lethal activity than avermectin.
- •
The preliminary SAR correlations were formulated.
- •
The built QSAR model provide insight to develop potential avermectin derivatives.