Shutting down the pore: The search for small molecule inhibitors of the mitochondrial permeability transition
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- 作者：Justina &Scaron ; ileikytėa ; Michael Forteb ; forte@ohsu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：PTP ; permeability transition pore ; OMM ; outer mitochondrial membrane ; IMM ; inner mitochondrial membrane ; CsA ; cyclosporin A ; CyPD ; cyclophilin D ; CyPA ; cyclophilin A ; F-ATP synthase ; FOF1 ATP synthase ; HTS ; high-throughput screening ; TRO40303 ; 3 ; 5-seco-4-nor-cholestan-5-one oxime-3-ol ; BN-PAGE ; blue-native polyacrylamide gel electrophoresis ; Rh123 ; rhodamine 123 ; CRC ; calcium retention capacity ; SAR ; structure/activity relationships ; CA ; cinnamic anilides ; MLSMR ; NIH Molecular Libraries Small Mo
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：1857
- 期：8
- 页码：1197-1202
- 全文大小：636 K
文摘
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Need for inhibitors of the mitochondrial permeability transition pore outlined
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Methods employed in high-throughput screens
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Three classes of inhibitors compared