Design of a Subtarsal Ultrasonic Transducer for Mild Hyperthermia Treatment of Dry Eye Disease

详细信息    查看全文

• 作者：Michael B. Hynes^&lowast ; ; ^&dagger ; ; Matthew C. Bujak^&Dagger ; ; Emmanuel Ché ; rin^&lowast ; ; Shachar Sade^§ ; ; ^¶ ; ; F. Stuart Foster^&lowast ; ; ^‖ ; ^{stuart@sri.utoronto.ca" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Dry eye disease ; Ultrasound hyperthermia ; Meibomian gland dysfunction
• 刊名：Ultrasound in Medicine & Biology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：42
• 期：1
• 页码：232-242
• 全文大小：1274 K

文摘

Dry eye disease is a disorder of the ocular surface that causes pain and low vision in a significant portion of the adult population. A common cause is obstructive Meibomian gland dysfunction, whereby the Meibomian glands secrete abnormal meibum with a melting point elevated by 3°C–4°C; hence, hyperthermia is the typical treatment. A design is proposed for an ultrasound hyperthermia device made of a transducer contained inside a contact lens with an internal air gap. The transducer heats the posterior of the tarsus, and the air gap provides an air backing to the transducer, preventing direct heating of the cornea. A prototype device was built, and hyperthermia experiments were performed on a porcine subject in vivo. A therapeutic temperature rise of 5°C–7°C was achievable in 10–15 min. The temperature of the cornea did not rise more than 2°C during any of the experiments.