PIAS1-mediated sumoylation promotes STUbL-dependent proteasomal degradation of the human telomeric protein TRF2
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- 作者：Joonyoung Hera ; Yu Young Jeonga ; In Kwon Chunga ; b ; topoviro@yonsei.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：TRF2 ; telomeric repeat binding factor 2 ; SUMO ; small ubiquitin-like modifiers ; PIAS1 ; protein inhibitor of activated STAT ; RNF4 ; ring-finger protein 4 ; SIM ; SUMO-interacting motif ; STUbL ; SUMO-targeted ubiquitin ligase ; ALT ; alternative lengthening of telomeres ; PML ; promyelocytic leukemia ; FISH ; fluorescent in situ hybridization ; DAPI ; 4 ; 6-diamino-2-phenylindole ; siRNA ; small interfering RNA
- 刊名：FEBS Letters
- 出版年：2015
- 出版时间：24 October 2015
- 年：2015
- 卷：589
- 期：21
- 页码：3277-3286
- 全文大小：1039 K
文摘
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TRF2 plays an essential role in the protection of chromosome ends.
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TRF2 interacts with and is sumoylated by PIAS1.
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RNF4 preferentially targets SUMO-conjugated TRF2 for ubiquitination.
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PIAS1-mediated sumoylation status of TRF2 controls the level of TRF2 at telomeres.