Animal extrapolation in preclinical studies: An analysis of the tragic case of TGN1412

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• 作者：Maë ; l Lemoine^a ; ^b ; ^{lemoine@univ-tours.fr}
• 关键词：Animal extrapolation ; Preclinical studies ; Experimental organism ; Prediction ; Mechanistic thinking
• 刊名：Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：61
• 期：Complete
• 页码：35-45
• 全文大小：623 K
• 卷排序：61

文摘

Animal extrapolation does not always consist in an inductive, analogical argument based on the observation of mechanisms. It often relies on the hypothesis of a mechanism with piecemeal support of various animal models, i.e., an amalgamation of evidence. It is reliable at predicting kinds of effects to be expected, but not at predicting their magnitude.