Pulmonary and hepatic injury after sub-chronic exposure to sublethal doses of microcystin-LR
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- 作者：Giovanna Marcella Cavalcante Carvalhoa ; Viní ; cius Rosa Oliveiraa ; Natá ; lia Vasconcelos Casquilhoa ; Andressa Cristine Pereira Araujoa ; Raquel Moraes Soaresb ; Sandra Maria F.O. Azevedob ; Karla Maria Pereira Piresc ; Samuel Santos Valenç ; ac ; Walter Araujo Zina ; walter_zin@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cyanobacteria ; Microcystin-LR ; Subchronic exposure ; Lung injury ; Liver inflammation
- 刊名：Toxicon
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：112
- 期：Complete
- 页码：51-58
- 全文大小：2842 K
文摘
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Mice were sub-chronically exposed to 10 low sub-lethal doses of microcystin-LR every other day.
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A dose-dependence was tested by exposing the mice to 4 different concentrations of the toxin.
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Lung mechanics, morphology, inflammation, and cytokines were measured. Liver was evaluated.
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Livers showed steatosis, necrosis, inflammation and a high degree of binucleated hepatocytes.
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All doses of microcystin damaged lung and liver, but 20 μg/kg yielded the worst lung inflammation.