Toxicity assessment of perfluorooctane sulfonate using acute and subchronic male C57BL/6J mouse models
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- 作者：Jiali Xinga ; c ; Gang Wanga ; c ; wanggang@jiangnan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Jichun Zhaoa ; Eryin Wanga ; Boxing Yinb ; Dongsheng Fangb ; Jianxin Zhaoa ; Hao Zhanga ; Yong Q. Chena ; Wei Chena ; c ; d ; chenwei66@jiangnan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Perfluorooctane sulfonate ; Acute toxicity ; Subchronic toxicity ; Apoptosis
- 刊名：Environmental Pollution
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：210
- 期：Complete
- 页码：388-396
- 全文大小：1644 K
文摘
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The acute and subchronic toxicity of PFOS was systematically investigated.
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The acute oral LD50 value for PFOS in C57BL/6J mice was 0.579 g/kg body weight.
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PFOS disrupted the homeostasis of antioxidative systems.
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PFOS induced hepatocellular apoptosis and triggered liver injury.