A 90-day subchronic toxicity study with sodium formononetin-3′-sulphonate (Sul-F) delivered to dogs via intravenous administration
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- 作者：Chunmei Lia ; Guisheng Lia ; Yonglin Gaob ; gylbill@163.com" class="auth_mail" title="E-mail the corresponding author ; Chengfeng Sunb ; Xiaoyan Wangb
- 关键词：Sodium formononetin-3&prime ; -sulphonate (Sul-F) ; Subchronic toxicity ; Dogs ; Intravenous administration
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：87-92
- 全文大小：496 K
文摘
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Sul-F, up to 300 mg/kg, induced recoverable vascular stimulation.
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Sul-F, up to 300 mg/kg, induced transient vomiting.
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A white crystal was found after urine volatilization in 300 mg/kg Sul-F treated animals.
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Under the conditions, NOAEL for Sul-F was 100 mg/kg in dogs.