Acute and subchronic (13-week) toxicity of fermented Acanthopanax koreanum extracts in Sprague Dawley rats
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- 作者：MyoungLae Choa ; Gi-Hae Shina ; Jae-Min Kima ; Jin-Ha Leea ; Sun-Ok Parkb ; Sang-Jong Leeb ; HyunMu Shinc ; Boo-Yong Leed ; Il-Jun Kange ; Ok-Hwan Leea ; loh99@kangwon.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fermented Acanthopanax koreanum ; Acute toxicity ; 13-week toxicity ; Blood biochemistry ; NOAEL
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：93-99
- 全文大小：492 K
文摘
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We investigate the acute and subchronic toxicity (13-week) of fermented Acanthopanax koreanum (FAK) extracts in SD rats.
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FAK did not produce mortality or any clinical signs in the male and female rats.
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The LD50 value of FAK was higher than 5000 mg/kg.
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The NOAEL of FAK was 2000 mg/kg/day for both sexes.