Knotty Zika Virus Blocks Exonuclease to Produce Subgenomic Flaviviral RNAs

详细信息    查看全文

• 作者：Nandan S. Gokhale¹ ; Stacy M. Horner¹ ; ² ; ^{stacy.horner@duke.edu}
• 关键词：Zika virus ; sfRNA ; xrRNA ; RNA structure ; Xrn1
• 刊名：Cell Host & Microbe
• 出版年：2017
• 出版时间：11 January 2017
• 年：2017
• 卷：21
• 期：1
• 页码：1-2
• 全文大小：336 K
• 卷排序：21

文摘

In a recent issue of Science, Akiyama et al. (2016) prove the existence of a pseudoknot that stabilizes a nuclease-resistant RNA structure in the 3′ untranslated region of Zika virus. This reinforced structure blocks the 5′→3′ exonuclease Xrn1 for the production of pathogenic subgenomic flaviviral RNAs.