YAP and p73: A Complex Affair

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• 作者：Julian Downward ; Subham Basu
• 刊名：Molecular Cell
• 出版年：2008
• 出版时间：26 December 2008
• 年：2008
• 卷：32
• 期：6
• 页码：749-750
• 全文大小：171 K

文摘

In this issue of Molecular Cell, Lapi et al. (2008) demonstrate that YAP binds p73 to activate PML transcription, which in turn mediates YAP sumoylation and stabilization, increases p73 activity, and thereby generates a DNA-damage-induced feedback loop.